A third HI 21-cm absorption system in the sight-line of MG J0414+0534: A redshift for Object X?

We report the detection of a third HI 21-cm absorber in the sight-line towards the z=2.64 quasar MG J0414+0534 (4C +05.19). In addition to the absorption at the host redshift and in the z=0.96 gravitational lens, we find, through a decimetre-wave spectral scan towards this source, strong absorption at z=0.38. We believe this may be associated with "Object X", an additional feature apparent in the field of the lensing galaxy and lensed images, on the basis of its close proximity to the quasar images and the possible detection of the [OIII] doublet in a published optical spectrum. If real, the strength of the [OIII] emission would suggest the presence of an active galactic nucleus, or a gas-rich galaxy undergoing rapid star formation, either of which is consistent with the strong outflows apparent in the 21-cm spectrum. Although this is the strongest intervening 21-cm absorber yet found, simultaneous observations failed to detect any of the 18-cm OH lines at the 21-cm redshift. This suggests that, as for the lensing galaxy, this is not the primary location of the intervening material responsible for the very red colour of MG J0414+0534.Comment: 5 pages, accepted by MNRAS Letter

Impact-Melt Populations in Apollo Drive-Tubes

No abstract availabl

Effects of anode material on arcjet performance

Anodes fabricated from four different materials were tested in a modular arcjet thruster at 1 kW power level on nitrogen/hydrogen mixtures. A two-percent thoriated tungsten anode served as the control. Graphite was chosen for its ease in fabrication, but experienced severe erosion in the constrictor and diverging side. Hafnium carbide and lanthanum hexaboride were chosen for their low work functions but failed due to thermal stress and reacted with the propellant. When compared to the thoriated tungsten nozzle, thruster performance was significantly lower for the lanthanum hexaboride insert and the graphite nozzle, but was slightly higher for the hafnium carbide nozzle. Both the lanthanum hexaboride and hafnium carbide nozzle operated at higher voltages. An attempt was made to duplicate higher performance hafnium carbide results, but repeated attempts at machining a second anode insert were unsuccessful. Graphite, hafnium carbide, and lanthanum hexaboride do not appear viable anode materials for low power arcjet thrusters

Harms and benefits associated with psychoactive drugs: findings of an international survey of active drug users.

There have been several recent efforts in the UK and the Netherlands to describe the harms of psychoactive substances based on ratings of either experts or drug users. This study aimed to assess the perceived benefits as well as harms of widely used recreational drugs, both licit and illicit, in an international sample of drug users. The survey was hosted at https://www.internationaldrugsurvey.org/ and was available in three languages. Residents reported their experience of 15 commonly used drugs or drug classes; regular users then rated their harms and benefits. In all, 5791 individuals from over 40 countries completed the survey, although the majority were from English speaking countries. Rankings of drugs differed across 10 categories of perceived benefits. Skunk and herbal cannabis were ranked consistently beneficial, whilst alcohol and tobacco fell below many classified drugs. There was no correlation at all between users' harm ranking of drugs and their classification in schedules of the USA or ABC system in the UK. Prescription analgesics, alcohol and tobacco were ranked within the top 10 most harmful drugs. These findings suggest that neither the UK nor US classification systems act to inform users of the harms of psychoactive substances. It is hoped the results might inform health professionals and educators of what are considered to be both the harms and benefits of psychoactive substances to young people

A condition-specific codon optimization approach for improved heterologous gene expression in Saccharomyces cerevisiae

All authors are with the Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX 78712, USA -- Hal S. Alper is with the Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway Avenue, Austin, TX 78712, USA -- Amanda M. Lanza Current Address: Bristol-Myers Squibb, Biologics Development, 35 South Street, Hopkinton, MA 01748, USABackground: Heterologous gene expression is an important tool for synthetic biology that enables metabolic engineering and the production of non-natural biologics in a variety of host organisms. The translational efficiency of heterologous genes can often be improved by optimizing synonymous codon usage to better match the host organism. However, traditional approaches for optimization neglect to take into account many factors known to influence synonymous codon distributions. Results: Here we define an alternative approach for codon optimization that utilizes systems level information and codon context for the condition under which heterologous genes are being expressed. Furthermore, we utilize a probabilistic algorithm to generate multiple variants of a given gene. We demonstrate improved translational efficiency using this condition-specific codon optimization approach with two heterologous genes, the fluorescent protein-encoding eGFP and the catechol 1,2-dioxygenase gene CatA, expressed in S. cerevisiae. For the latter case, optimization for stationary phase production resulted in nearly 2.9-fold improvements over commercial gene optimization algorithms. Conclusions: Codon optimization is now often a standard tool for protein expression, and while a variety of tools and approaches have been developed, they do not guarantee improved performance for all hosts of applications. Here, we suggest an alternative method for condition-specific codon optimization and demonstrate its utility in Saccharomyces cerevisiae as a proof of concept. However, this technique should be applicable to any organism for which gene expression data can be generated and is thus of potential interest for a variety of applications in metabolic and cellular engineering.Chemical EngineeringInstitute for Cellular and Molecular [email protected]

Using 21-cm absorption surveys to measure the average HI spin temperature in distant galaxies

We present a statistical method for measuring the average HI spin temperature in distant galaxies using the expected detection yields from future wide-field 21cm absorption surveys. As a demonstrative case study we consider a simulated all-southern-sky survey of 2-h per pointing with the Australian Square Kilometre Array Pathfinder for intervening HI absorbers at intermediate cosmological redshifts between $z = 0.4$ and $1$. For example, if such a survey yielded $1000$ absorbers we would infer a harmonic-mean spin temperature of $\overline{T}_\mathrm{spin} \sim 100$K for the population of damped Lyman $\alpha$ (DLAs) absorbers at these redshifts, indicating that more than $50$ per cent of the neutral gas in these systems is in a cold neutral medium (CNM). Conversely, a lower yield of only 100 detections would imply $\overline{T}_\mathrm{spin} \sim 1000$K and a CNM fraction less than $10$ per cent. We propose that this method can be used to provide independent verification of the spin temperature evolution reported in recent 21cm surveys of known DLAs at high redshift and for measuring the spin temperature at intermediate redshifts below $z \approx 1.7$, where the Lyman-$\alpha$ line is inaccessible using ground-based observatories. Increasingly more sensitive and larger surveys with the Square Kilometre Array should provide stronger statistical constraints on the average spin temperature. However, these will ultimately be limited by the accuracy to which we can determine the HI column density frequency distribution, the covering factor and the redshift distribution of the background radio source population.Comment: 11 pages, 9 figures, 1 table. Proof corrected versio

A fourth HI 21-cm absorption system in the sight-line of MG J0414+0534: a record for intervening absorbers

We report the detection of a strong HI 21-cm absorption system at z=0.5344, as well as a candidate system at z=0.3389, in the sight-line towards the z=2.64 quasar MG J0414+0534. This, in addition to the absorption at the host redshift and the other two intervening absorbers, takes the total to four (possibly five). The previous maximum number of 21-cm absorbers detected along a single sight-line is two and so we suspect that this number of gas-rich absorbers is in some way related to the very red colour of the background source. Despite this, no molecular gas (through OH absorption) has yet been detected at any of the 21-cm redshifts, although, from the population of 21-cm absorbers as a whole, there is evidence for a weak correlation between the atomic line strength and the optical--near-infrared colour. In either case, the fact that so many gas-rich galaxies (likely to be damped Lyman-alpha absorption systems) have been found along a single sight-line towards a highly obscured source may have far reaching implications for the population of faint galaxies not detected in optical surveys, a possibility which could be addressed through future wide-field absorption line surveys with the Square Kilometre Array.Comment: Accepted by ApJ Letter

The Carrington event not observed in most ice core nitrate records

The Carrington Event of 1859 is considered to be among the largest space weather events of the last 150 years. We show that only one out of 14 well-resolved ice core records from Greenland and Antarctica has a nitrate spike dated to 1859. No sharp spikes are observed in the Antarctic cores studied here. In Greenland numerous spikes are observed in the 40 years surrounding 1859, but where other chemistry was measured, all large spikes have the unequivocal signal, including co-located spikes in ammonium, formate, black carbon and vanillic acid, of biomass burning plumes. It seems certain that most spikes in an earlier core, including that claimed for 1859, are also due to biomass burning plumes, and not to solar energetic particle (SEP) events. We conclude that an event as large as the Carrington Event did not leave an observable, widespread imprint in nitrate in polar ice. Nitrate spikes cannot be used to derive the statistics of SEPs

Comment on “Low time resolution analysis of ice cores cannot detect impulsive nitrate events” by D. F. Smart et al.

Smart et al. (2014) suggested that the detection of nitrate spikes in polar ice cores from solar energetic particle (SEP) events could be achieved if an analytical system with sufficiently high resolution was used. Here we show that the spikes they associate with SEP events are not reliably recorded in cores from the same location, even when the resolution is clearly adequate. We explain the processes that limit the effective resolution of ice cores. Liquid conductivity data suggest that the observed spikes are associated with sodium or another nonacidic cation, making it likely that they result from deposition of sea salt or similar aerosol that has scavenged nitrate, rather than from a primary input of nitrate in the troposphere. We consider that there is no evidence at present to support the identification of any spikes in nitrate as representing SEP events. Although such events undoubtedly create nitrate in the atmosphere, we see no plausible route to using nitrate spikes to document the statistics of such events